Resources
121 Результаты связано с Synergy Neo2 Hybrid Multi-Mode Reader:
Руководства по примнению
- Multi-Volume Based Protein Quantification Methods (January 31, 2013)
- High Throughput Screening Applications (January 31, 2013)
- Automated Non-Radioactive Assay Methods For ADCC and CDC Assays (January 21, 2013)
- Synergy™ NEO HTS Multi-Mode Microplate Reader and Life Technologies Reagents (October 8, 2012)
- Synergy™ Microplate Readers and HTRF® Detection (September 27, 2012)
Application Bulletins
Статьи по применению
- A Homogeneous FRET-based HTS Assay for Quantification of pRb in Cancer Cell Lines to Monitor Inhibition of G0/ G1 Cell Phase Transition (April 21, 2020)
- A High-Throughput Luminescence-Based Live Cell Assay to Measure ß-Arrestin Recruitment in Real Time (April 4, 2019)
- Rapid Measurement of IgG Using Fluorescence Polarization (September 15, 2017)
- Monitoring of Protein Kinase Activity Using Next Generation CSox-based Substrate Sensors (August 2, 2017)
- Protein Quantitation using NanoOrange® Fluorescence (January 26, 2017)
- Fluorometric Quantitation of dsDNA using PicoGreen® (January 25, 2017)
- Investigation of Protein: Protein Interactions (PPI) using a Novel Bioluminescence Resonance Energy Transfer (BRET) Proximitybased, High Throughput Screening Assay (June 17, 2016)
- Comparative Analysis of Dual-Luciferase® Assay Technologies in a High Throughput Microplate Format (March 18, 2016)
- High Throughput, Multiplexed Detection of Inflammatory Cytokines in an Astrocyte and Monocyte Co-culture Model (February 18, 2016)
- Low-volume, High Throughput Workflow for Analysis of Nucleic Acid Samples for Biobanking (December 18, 2015)
- Utility of Variable Bandwidth Monochromators for Quantification of Fluorescent Probes in Produced Effluent Water (July 1, 2015)
- Combining Kinetic Ligand Binding and 3D Tumor Invasion Technologies to Assess Drug Residence Time and Anti-metastatic Effects of CXCR4 Inhibitors (April 16, 2015)
- Automation of a HTRF® Universal Methyltransferase Assay (December 23, 2014)
- Detection of Human IgG Using a Luminescence-based Proximity Assay (December 5, 2014)
- UV Fluorescence Polarization as a Means to Investigate Protein Conformational and Mass Change - Using Intrinsic Tryptophan Fluorescence in Conjunction with UV-capable Polarizers (October 13, 2014)
- Rapid Critical Micelle Concentration (CMC) Determination Using Fluorescence Polarization (September 18, 2014)
- Live Cell Biosensor Assay Used To Interrogate GPCRs - Comparative Analysis of Biosensor Variants (November 8, 2013)
- Validation and Comparison of Single-Step Flash and Dual-Spectral Luciferase Reporter Gene Assays using the Synergy™ Line of Microplate Readers (October 16, 2013)
- Automation of a Homogeneous Proximity Assay for Immunogenicity Testing of Biological Drug Products (June 5, 2013)
- Assessment of HDAC1 Inhibition Using an Automated, Bioluminescent Histone Deacetylase I/II Assay (March 27, 2013)
- Automation of Optimiser™ Microplate Technology for High Throughput Applications (March 13, 2013)
- Automated, High Throughput, HTRF®-Based Detection of Histone Methyltransferase and Demethylase Enzyme Activity (March 5, 2013)
- Interrogation of SET7/9 Histone Lysine Methyltransferase Using a High Throughput Fluorescence Polarization Screening Assay (February 12, 2013)
- Analysis of a New High Throughput Screening Detection Technology for Rapid hERG Safety Testing using a Fluorescence Polarization Assay (February 12, 2013)
- BRD4 Bromodomain 1 Inhibitor Screening using a Homogeneous Proximity Assay (February 11, 2013)
- Automating a Direct, Cell-Based, Target-Compound Interaction Assay for G9a Histone Methyltransferase and Bromodomain Proteins (February 8, 2013)
- Automated, High Throughput Methods for the Quantification of Endogenous Cellular Kinase Activity using HTRF Technology (January 28, 2013)
- Determination of Endogenous Cellular Kinase Activity Through the Use of an Automated, High Throughput AlphaScreen®-Based Assay (September 13, 2012)
- Rapid Screening of a Cell-based Assay for GLP-1 Receptor Using a Natural Product Library (August 7, 2012)
Цитаты
Детектирование
Synergy Neo2 Hybrid Multi-Mode Reader (49)
- Max J. Kellner, Jeremy G. Koob, Jonathan S. Gootenberg, Omar O. Abudayyeh and Feng Zhang (2019) "SHERLOCK: nucleic acid detection with CRISPR nucleases." Nature Protocols
- Lavogina, D;Samuel, K;Lavrits, A;Meltsov, A;Sõritsa, D;Kadastik, Ü;Peters, M;Rinken, A;Salumets, A; (2019) "Chemosensitivity and chemoresistance in endometriosis - differences for ectopic versus eutopic cells." Reprod. Biomed. Online
- Lavogina, D;Samuel, K;Lavrits, A;Meltsov, A;Sõritsa, D;Kadastik, ;Peters, M;Rinken, A;Salumets, A; (2019) "Chemosensitivity and chemoresistance in endometriosis – differences for ectopic versus eutopic cells." Reproductive BioMedicine Online
- Okomo-Adhiambo, M;Mishin, VP;Sleeman, K;Saguar, E;Guevara, H;Reisdorf, E;Griesser, RH;Spackman, KJ;Mendenhall, M;Carlos, MP;Healey, B;St George, K;Laplante, J;Aden, T;Chester, S;Xu, X;Gubareva, LV; (2016) "Standardizing the influenza neuraminidase inhibition assay among United States public health laboratories conducting virological surveillance." Antiviral Res.
- Andrea C. Rodriguez, Seok-Ho Yu, Bin Li, Hicham Zegzouti, Jennifer J. Kohler (2015-08-03) "Enhanced Transfer of a Photocross-linking N-Acetylglucosamine (GlcNAc) Analog by an O-GlcNAc Transferase Mutant with Converted Substrate Specificity." Journal of Biological Chemistry
- Wei Li, Jie Li, Weibing Qiang, Jingjuan Xua, Danke Xu (2013) "Enzyme-free colorimetric bioassay based on gold nanoparticle-catalyzed dye decolorization." Analyst
- Lukasz Skora, Dominique Kempf, Jürgen Mestan, Daniel D'Orazio, Wolfgang Jahnke (2015-07-22) "Phosphorylation of Tyr245 in the open‐inhibited state of Abelson kinase does not induce downstream signaling." European Journal of Haematology
- Citation: Inoue M, Akama T, Jiang Y, Chun T-H (2015) "The Exocyst Complex Regulates Free Fatty Acid Uptake by Adipocytes." PLoS ONE
- Da‑An Zhou, Yue‑Ning Deng, Lei Liu, Jian‑Jun Li (2014-11-11) "Effect of kidney-reinforcing and marrow-beneficial traditional Chinese medicine-intervened serum on the proliferation and osteogenic differentiation of bone marrow stromal cells." Spandidos Publications
- Wei Li, Weibing Qiang, Jie Li, Hui Li, Yifan Dong, Yaju Zhao, Danke Xu (2014-01-15) "Nanoparticle-catalyzed reductive bleaching for fabricating turn-off and enzyme-free amplified colorimetric bioassays." Biosensors and Bioelectronics
- Xun Chi, Shwetha K. Shetty, Hannah W. Shows, Alexander J. Hjelmaas, Emily K. Malcolm and Brandon S. J. Davies (2015-05-08) "Angiopoietin-like 4 Modifies the Interactions between Lipoprotein Lipase and Its Endothelial Cell Transporter GPIHBP1." The Journal of Biological Chemistry
- Xiaojing Liu, Shuai Han, Ying Yang, Jiuhong Kang, Jiarui Wua (2015-08-28) "Glucose-induced glutathione reduction in mitochondria is involved in the first phase of pancreatic β-cell insulin secretion." Biochemical and Biophysical Research Communications
- Shailender Singh Kanwar, Christopher James Dunlay, Diane M. Simeonecde, Sunitha Nagrath (2014) "Microfluidic device (ExoChip) for on-chip isolation, quantification and characterization of circulating exosomes." Lab Chip
- Richard Laga*, Olga Janoušková, Karel Ulbrich, Robert Pola, Jana Blažková, Sergey K. Filippov, Tomáš Etrych, and Michal Pechar (2015) "Thermoresponsive Polymer Micelles as Potential Nanosized Cancerostatics." Biomacromolecules
- Nivedita U. Jerath, Cameron D. Crockett, Steven A. Moore, Michael E. Shy, Conrad C. Weihl, Tsui-Fen Chou, Tiffany Grider, Michael A. Gonzalez, Stephan Zuchner, and Andrea Swenson (2015) "Rare Manifestation of a c.290 C>T, p.Gly97Glu VCP Mutation." Hindawi
- Fatih Kocabas, Galip S. Aslan (2015-10) "Fluorometric CCHFV OTU protease assay with potent inhibitors." Virus Genes
- Qunfang Yan, Yuchi Yang, Wulian Chen, Jianhua Hu, Dong Yang (2016-01-01) "Construction of polymer–paclitaxel conjugate linked via a disulfide bond." Materials Science and Engineering: C
- Karel Domansky, Daniel C. Leslie, James McKinney, Jacob P. Fraser, Josiah D. Sliz, Tiama Hamkins-Indik, Geraldine A. Hamilton, Anthony Bahinski, Donald E. Ingber (2013) "Clear castable polyurethane elastomer for fabrication of microfluidic devices." Lab Chip
- Liubing Li, Jun Gu, Jie Zhang, Zonggang Xie, Yufeng Lu, Liqin Shen, Qirong Dong, and Yangyun Wang (2015-04-10) "Injectable and Biodegradable pH-Responsive Hydrogels for Localized and Sustained Treatment of Human Fibrosarcoma." ACS Appl. Mater. Interfaces
- Yuchen Fan, Preety Sahdev, Lukasz J. Ochyl, Jonathan J. Akerberg, James J. Moon (2015-06-28) "Cationic liposome–hyaluronic acid hybrid nanoparticles for intranasal vaccination with subunit antigens." Journal of Controlled Release
- Robert J. Gallagher, Chitra Subramanian, Patrick T. Grogan, Kelly Kindscher, Cong-Mei Cao, Huaping Zhang, Mark S. Cohen, Barbara N. Timmermann (2015) "The therapeutic potential of Physalis longifolia against various carcinomas." PharmaNutrition
- Gustavo B. Leite, Kiran Paranjape, Ahmed E.M. Abdelaziz, Patrick C. Hallenbeck (2015-05) "Utilization of biodiesel-derived glycerol or xylose for increased growth and lipid production by indigenous microalgae." Bioresource Technology
- Daniel Horak, Uliana Kostiv, Olga Janoušková, Miroslav Slouf, Nikolay Kotov, Hana Engstova, Katarina Smolkova and Petr Jezek (2015) "Silica-modified monodisperse hexagonal lanthanide nanocrystals: Synthesis and biological properties." Nanoscale
- Tyler J. Ford, Jeffrey C. Way (2015-06-30) "Enhancement of E. coli acyl-CoA synthetase FadD activity on medium chain fatty acids." PeerJ
- Sergio Wehinger, Rina Ortiz, María Inés Díaz, Adam Aguirre, Manuel Valenzuela, Paola Llanos, Christopher Mc Master, Lisette Leyton, Andrew F.G. Quest (2015) "Phosphorylation of Caveolin-1 on tyrosine-14 induced by ROS enhances palmitate-induced death of beta-pancreatic cells." Biochimica et Biophysica Acta
- Carlos Sandoval-Jaime, Kim Y. Green, Stanislav V. Sosnovtsev (2015-06-01) "Recovery of murine norovirus and feline calicivirus from plasmids encoding EMCV IRES in stable cell lines expressing T7 polymerase." Journal of Virological Methods
- Xu Qian, Luis G. Villa-Diaz, Ramya Kumar, Joerg Lahann, Paul H. Krebsbach (2014-12) "Enhancement of the propagation of human embryonic stem cells by modifications in the gel architecture of PMEDSAH polymer coatings." Biomaterials
- Chen Chu, Guangyong Zheng, Shuanggang Hu, Jinsong Zhang, Shengsong Xie, Wubin Ma, Minjie Ni, Chunhua Tang, Lu Zhou, Yuchuan Zhou, Mofang Liu, Yixue Li , Yonglian Zhang (2015-04) "Epididymal Region-Specific miRNA Expression and DNA Methylation and Their Roles in Controlling Gene Expression in Rats." PLoS ONE
- Anna H. Chen, David Lubkowicz, Vivian Yeong, Roger L. Chang, Pamela A. Silver (2015-06-12) "Transplantability of a circadian clock to a noncircadian organism." Science Advances
- Jinsook Kim, Insil Song, Ara Jo, Joo-Ho Shin, Hana Cho, Robert L. Eoff, F. Peter Guengerich, and Jeong-Yun Choi (2014) "Biochemical Analysis of Six Genetic Variants of Error-Prone Human DNA Polymerase ι Involved in Translesion DNA Synthesis." Chem. Res. Toxicol.
- J T Poirier, E E Gardner, N Connis, A L Moreira, E de Stanchina, C L Hann and C M Rudin (2015-03-09) "DNA methylation in small cell lung cancer defines distinct disease subtypes and correlates with high expression of EZH2." Oncogene
- Jie Li, Wei Li, Weibing Qiang, Xi Wang, Hui Li, Danke Xu (2014-1-7) "A non-aggregation colorimetric assay for thrombin based on catalytic properties of silver nanoparticles." Analytica Chimica Acta
- Weibing Qiang, Haiping Liu, Wei Li, Xiang Chen, Danke Xu (2014-5-30) "Label-free detection of adenosine based on fluorescence resonance energy transfer between fluorescent silica nanoparticles and unmodified gold nanoparticles." Anal Chim Acta
- Fagan RL, Wu M, Chédin F, Brenner C (2013) "An Ultrasensitive High Throughput Screen for DNA Methyltransferase 1-Targeted Molecular Probes." PLoS ONE
- Fagan, R. L., Cryderman, D. E., Kopelovich, L., Wallrath, L. L., & Brenner, C. (2013-7-9) "Laccaic Acid A Is a Direct, DNA-competitive Inhibitor of DNA Methyltransferase 1." Journal of Biological Chemistry
- Gottfried-Blackmore, A., Jellinck, P. H., Vecchiarelli, H. A., Masheeb, Z., Kaufmann, M., McEwen, B. S., & Bulloch, K. (2013) "7α-hydroxylation of dehydroepiandrosterone does not interfere with the activation of glucocorticoids by 11β-hydroxysteroid dehydrogenase in E(t)C cerebellar neurons." The Journal of steroid biochemistry and molecular biology
- Kasap, C., Elemento, O., & Kapoor, T. M. (2014-6-15) "DrugTargetSeqR: a genomics- and CRISPR-Cas9–based method to analyze drug targets." Nature chemical biology
- Kinge, C. N. W., Espiritu, C., Prabdial-Sing, N., Sithebe, N. P., Saeed, M., & Rice, C. M. (2014-9) "Hepatitis C virus genotype 5a subgenomic replicons for evaluation of direct-acting antiviral agents." Antimicrobial agents and chemotherapy
- Lee, D., Bolton, O., Kim, B. C., Youk, J. H., Takayama, S., & Kim, J. (2013) "Room Temperature Phosphorescence of Metal-Free Organic Materials in Amorphous Polymer Matrices." Journal of the American Chemical Society
- Sophocleous, A. M., Desai, K. G. H., Mazzara, J. M., Tong, L., Cheng, J. X., Olsen, K. F., & Schwendeman, S. P. (2013) "The nature of peptide interactions with acid end-group PLGAs and facile aqueous-based microencapsulation of therapeutic peptides." Journal of Controlled Release
- Tiong, S. H., Looi, C. Y., Hazni, H., Arya, A., Paydar, M., Wong, W. F., ... & Awang, K. (2013) "Antidiabetic and Antioxidant Properties of Alkaloids from Catharanthus roseus (L.) G. Don." Molecules
- Rodriguez, A., & Kohler, J. (2014) "Recognition of diazirine-modified O-GlcNAc by human O-GlcNAcase." MedChemComm.
- Liesch, J., Bellani, L. L., & Vosshall, L. B. (2013) "Functional and Genetic Characterization of Neuropeptide Y-Like Receptors in Aedes aegypti." PLoS neglected tropical diseases
- Esvelt, K. M., Mali, P., Braff, J. L., Moosburner, M., Yaung, S. J., & Church, G. M. (2013) "Orthogonal Cas9 proteins for RNA-guided gene regulation and editing." Nature methods
- Sun, T., Warrington, N. M., Luo, J., Brooks, M. D., Dahiya, S., Snyder, S. C., ... & Rubin, J. B. (2014-8-1) "Sexually dimorphic RB inactivation underlies mesenchymal glioblastoma prevalence in males." The Journal of clinical investigation
- Chou, T. F., Bulfer, S. L., Weihl, C. C., Li, K., Lis, L. G., Walters, M. A., ... & Arkin, M. R. (2014) "Specific Inhibition of p97/VCP ATPase and Kinetic Analysis Demonstrate Interaction between D1 and D2 ATPase domains." Journal of Molecular Biology
- Frampton, J. P., White, J. B., Simon, A. B., Tsuei, M., Paczesny, S., & Takayama, S. (2014-5-2) "Aqueous two-phase system patterning of detection antibody solutions for cross-reaction-free multiplex ELISA." Scientific reports, 4.
- Pencheva, N., Buss, C. G., Posada, J., Merghoub, T., & Tavazoie, S. F. (2014) "Broad-spectrum therapeutic suppression of metastatic melanoma through nuclear hormone receptor activation." Cell
- Hudson WH, Youn C, Ortlund EA (2013-01) "The structural basis of direct glucocorticoid-mediated transrepression." NCBI
Научные постеры
- A Homogeneous FRET-based HTS Assay for quantification of pRb in Breast Cancer Cell Lines to monitor inhibition of GO / G1 cell phase transition (September 23, 2019)
- Investigation of a Novel, High-throughput Method for Real-time Measurement of β-arrestin Recruitment using a Live-cell Luminescence Based Assay System (February 6, 2019)
- Next Generation CSox-based Substrate Sensors for Continuous, Homogeneous and Quantitative Monitoring of Protein Kinase Activity (February 13, 2017)
- The Utility of Drug Residence Time for the Assessment of Inhibitor Potency (February 4, 2016)
- High Throughput, Multiplexed Detection of Inflammatory Cytokines in an Astrocyte and Monocyte Co-culture Model (February 4, 2016)
- Investigation of Protein:Protein Interactions (PPI) using a novel Bioluminescence Resonance Energy Transfer (BRET) Proximity-based, High-Throughput Screening Assay (February 3, 2016)
- Combining Kinetic Ligand Binding and 3D Tumor Invasion Technologies to Assess Drug Residence Time and anti-Metastatic Effects of CXCR4 Inhibitors (February 13, 2015)
- Optimization of a multi-mode detection model for measuring real-time cellular respiration and mitochrondrial function using fluorophoric biosensors (February 13, 2015)
- Automated, High Throughput, HTRF®-Based Detection of Histone Methyltransferase and Demethylase Enzyme Activity (January 14, 2013)
- An Automated Profiling Application using a Direct, Cell-Based, Target-Compound Interaction Assay for G9a Histone Methyltransferase and Bromodomain Proteins (January 14, 2013)
- Automation of a Homogeneous Proximity Assay for Immunogenicity Testing of Biological Drug Products (January 14, 2013)
- Live-Cell Biosensor Assay Used To Interrogate GPCRs: Comparative Analysis of Biosensor Variants (January 14, 2013)
- Rapid Screening of a Cell-based Assay for GLP-1 Receptor Using a Natural Product Library (January 14, 2013)
- An Automated, High Throughput Method for the Quantification of Endogenous Cellular Kinase Activity (January 14, 2013)
- Screening for Inhibitors of BRD4 Bromodomain 1 using a Homogeneous Proximity Assay (January 14, 2013)
- Analysis of a New High Throughput Screening Detection Technology for Rapid hERG Safety Testing using a Fluorescence Polarization Assay (January 14, 2013)
- Determination of Endogenous Cellular Kinase Activity through the Use of an Automated, High Throughput AlphaScreen®-Based Method (January 14, 2013)
- Determination of Endogenous Cellular Kinase Activity through the Use of an Automated, High Throughput AlphaScreen®-Based Method (September 28, 2012)
- An Automated, High Throughput Method for the Quantification of Endogenous Cellular Kinase Activity (September 28, 2012)
- Rapid Screening of a Cell-based Assay for GLP-1 Receptor Using a Natural Product Library (September 28, 2012)
Технические статьи
- Qubit Assay using Synergy™ Neo2 (March 13, 2020)
- Fluorescence Determinations Using the Extended Dynamic Range Measurement Option of the Synergy™ Neo2 (November 3, 2015)
- Angled Dispenser Tips for Reagent Addition to Live Cells (June 16, 2014)
- Fluorescent Proteins Wavelength Maxima and Suggested Filter Combinations (January 29, 2013)
Visual Abstracts
Вебинары
- ELISA: Best Practices and Troubleshooting - On Demand (September 20, 2017)
- Flexibility and High Assay Performance with a Hybrid Multi-Mode Microplate Reader (August 31, 2015)
- New, Advanced Tools for Smarter Screening of Small Molecule Drug Targets (March 21, 2013)
- Synergy™ NEO: A New HTS Multi-Mode Microplate Reader Designed for Today’s Smarter Screening (February 20, 2013)
- New, Automated Non-Radioactive Assay Technologies for Use in Antibody-Dependent Cell-Mediated Cytotoxicity Applications (November 16, 2012)